Lawrence Shapiro, Director

Positions

• 2001- Associate Professor, Columbia University, Department of Biochemistry and Molecular Biophysics and Edward S. Harkness Eye
  Institute, Member, Naomi Berrie Diabetes Center
• 1997-2001 Assistant Professor, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York
• 1996-1997 Associate Research Scientist, Columbia University Department of Biochemistry and Molecular Biophysics (W.A. Hendrickson Lab)

Publications

• G Protein Signaling through Tubby Proteins, Santagata, S., Gomez, C., Shan, W.S., Baird, C.L., Zhao, J., Myszka, D., and Shapiro, L. (2001) Science, 292, 2041-2050.
• The presynaptic particle web: Ultrastructure, composition, dissolution and reconstitution, Phillips, G.R., Huang,J.K., Wang,Y. Tanaka, H., Shapiro, L., Zhang, W., Shan, W., Arndt, K., Frank, M., Gordon, R.E., Gawinowicz, M.A., Zhao, Y., and Colman, D.R. (2001) Neuron, 32, 63-77.
• Making memories stick: cell adhesion molecules in synaptic plasticity, Benson, D.L., Schnapp, L.M., Shapiro, L., and Huntley, G.W. (2000) Trends Cell Biol., 10, 473-482.
• Screening for phasing atoms in protein crystallography, Boggon, T.J. and Shapiro, L. (2000) Structure 8, R143-149.
• Finding function through structural genomics, Shapiro, L. and Harris, T. (2000) Current Opinion in Biotechnology, 11, 31-35.
• Functional cis heterodimers of N- and R-cadherins, Shan, W.-S., Colman, D.R., and Shapiro, L. (2000) Journal of Cell Biology, 148, 579-590.
• Molecular modification of N-cadherin in response to synaptic activity, Tanaka, H., Shan, W., Phillips, G.R., Arndt, K., Bozdagi, O., Shapiro, L., Huntley, G.W., Benson, D.L., and Colman, D.R. (2000) Neuron, 25, 93-107.
• LPS activated TLR-4 receptor induces synthesis of the closely related receptor TLR-2 in adipocytes, Lin, Y., Lee, H., Berg, A.H., Lisanti, M.P., Shapiro, L., and Scherer, P.E. (2000) J. Biol. Chem, 275, 24255-24263.
• Implication of tubby proteins as transcription factors by structure-based functional analysis, Boggon, T.J., Shan, W.-S., Santagata, S. Myers, S.C., and Shapiro, L. (1999) Science, 286, 2119-2125.
• Predominant expression of the mitochondrial dicarboxylate carrier in white adipose tissue, Das, K., Lewis, R.Y., Combatsiaris, T.P., Lin, Y., Shapiro, L., Charron, M.J., and Scherer P.E. (1999) Biochem J., 344, 313-320.
• The adhesive binding site of cadherins revisited, Shan, W.-S., Koch, A., Murray, J., Colman, D.R., and Shapiro, L. (1999) Biophysical Chemistry, 82, 157-163.
• The diversity of cadherins and implications for a synaptic adhesive code, Shapiro, L., and Colman, D.R. (1999) Neuron, 23, 427-430.
• Structural biology of cadherins in the nervous system, Shapiro, L., and Colman, D.R. (1998) Current Opinion in Neurobiology, 8, 593-599.
• Structure-function analysis of cell adhesion by neural (N-) cadherin, Tamura, K., Shan, W.-S., Hendrickson, W.A., Colman, D.R., and Shapiro, L. (1998) Neuron, 20, 1153-1163
• The Argonne Structural Genomics workshop: Lamaze class for the birth of a new science, Shapiro, L., and Lima, C.D. (1998) Structure, 6, 265-267
• The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor, Shapiro, L., and Scherer, P.E. (1998) Current Biology, 8, 335-338
• The Multi-Talented b-Catenin Makes its First Appearance, Shapiro, L. (1997) Structure, 5, 1265-1268
  Crystal Structure of the Extracellular Domain from P0, the Major Strcutural Protein of Peripheral Nerve Myelin, Shapiro, L., Doyle, J.P., Hensley, P., Coman, D.R., and Hendrickson, W.A. (1996) Neuron, 17, 435-449
• Structural Basis of Cell-Cell Adhesion by Cadherins, Shapiro, L., Fannon, A.M., Kwong, P.D., Thompson, A., Lehmann, M.S., Grübel, G., LeGrand, J.-F., Als-Nielsen, J., Colman, D.R., and Hendrickson, W.A. (1995) Nature, 374, 327-337
• Considerations on the Folding Topology and Evolution of Cadherin Domains, Shapiro, L., Kwong, P.D., Fannon, A.M., Colman, D.R., and Hendrickson, W.A. (1995) Proc. Natn. Acad Sci. USA, 92, 6793-6797
• NMR Relaxation Matrix Refinement of a DNA Octamer Solution Structure, Shapiro, L., Nilges, M., and Eriksson, M. (1993) Acta Chem. Scand., 47, 43-56
• Phospholipase A2 Modulation by Calmodulin, Prostaglandins, and Cyclic Nucleotides, Moskowitz, N., Shapiro, L., Schook, W., and Puszkin, S., (1983) Biochem. Biophy. Res. Comm., 115, 94-99
• Isolation and Preliminary Characterization of Clathrin-Associated Proteins, Lisanti, M.P., Shapiro, L., Moskowitz, N., Hua, E.L., Puszkin, S., and Schook, W. (1982) Eur. J. Biochem., 125, 463-470