Rudolph Leibel, Co-Director

Positions

• 1968-71 Major,U.S. Army Medical Corps
• 1972-74 NIH Clinical and Research Fellow in Peds Endocrinology-Metabolism, Massachusetts General Hospital
• 1975-78 Research Associate, Department of Nutrition and Food Science, Massachusetts Institute of Technology
• 1978-81 Rockefeller Scholar in Clinical Science, Rockefeller University
• 1985-89 Established Investigator, American Heart Association
• 1972-74 Instructor in Pediatrics, Massachusetts General Hospital, Harvard University Medical School
• 1974-78 Assistant Professor of Pediatrics, Massachusetts General Hospital, Harvard University Medical School
• 1978-97 Assistant Professor, Associate Professor, Laboratory Head, Rockefeller University
• 1990- Deputy Director, New York Obesity Research Center
• 1993-97 Professor of Pediatrics, Cornell University Medical College
• 1997- Adjunct Professor, Rockefeller University
• 1997 Professor of Pediatrics and Medicine, Head, Div. Of Molecular Genetics, Columbia University
• 1998 - Co-Director, Naomi Berrie Diabetes Center, Columbia University

Selected publications

• Rosenbaum M. and R.L. Leibel. The role of leptin in human physiology. N. Engl J Med 341:913-915, 1999.
• Wildman, H.F., S.C. Chua, R.L. Leibel and G.P. Smith. Effects of leptin and cholecystokinin in rats with the Koletsky mutation of the leptin receptor Leprfaf. Am J Physiol. 278:R1518-23, 2000.
• Lee M.S., M.P. Wajnrajch, S.S. Kim, L.P. Plotnick, J. Wang, J.M. Gertner, R.L. Leibel, P.S. Dannies. Autosomal dominant growth hormone (GH) deficiency type II: the Del32-71-GH deletion mutant suppresses secretion of wild-type GH. Endocrinology 141:883-890, 2000.
• Wajnrajch, M.P., I.S. Ten, J.M Gertner, and R.L. Leibel. Genomic organization of the human GHRELIN gene. J Endoc Genetics 1:231-233, 2000
• Kowalski, T.J., S-M. Liu, R.L. Leibel and S.C. Chua. Transgenic complement of leptin receptor deficiency: Rescue of the obesity/diabetes phenotype of Lepr-null mice expressing a Lepr-B transgene. Diabetes 50:425-435, 2001
• Zhang, Y., Hufnagel, C., Eiden, S., Guo, K-Y., Diaz, P.A., Leibel, R.L., and Schmidt, I. Mechanisms underlying differential regulation of leptin gene expression in brown and white adipose tissues of suckling rat pups segregating for the Leprfa mutation . Physiological Genomics. 4:189-199, 2001.
• Boozer, C.N., R.L. Leibel, RL.. Love, M.C. Chua and L. J. Aronne. Synergy of Sibutramine and low dose leptin in treatment of diet-induced obesity in rats. Metabolism. 50:889-93. 2001
• Heo, M., R.L. Leibel, et al. Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity. Genetics. 159:1163-1178, 2001.
• Ferrante, A.W., Thearle, M., Liao, T., Leibel, RL. Effects of leptin deficiency and short-term repletion on hepatic gene expression in genetically obese mice. Diabetes. 50: 2268-78. 2001.
• Leibel, R.L., Chua, S., Rosenbaum, M. Obesity. The Metabolic and Molecular Basis of Inherited Disease. 8th Edition Scriver, et al, eds, 2001. pp 3965-4028
• Zhang, Y., Guo, K.Y., Diaz, P.A., Heo, M., and Leibel, R.L. Determinants of leptin gene expression in fat depots of lean mice. Am.J. Physiol. In Press. 2001.