Matthias J. Szabolcs, M.D., Associate Professor of Clinical Pathology

Positions and Honors

• 2002-present Assistant Professor of Pathology
• 2000-2002 College of Physicians and Surgeons, Columbia University Assistant Professor of Pathology
• 1998-2000 University of Minnesota Assistant Professor of Clinical Pathology
• 1994-1998 College of Physicians and Surgeons, Columbia University
• 1985 Dr Eugen Grabscheid Prize
• 1986 Prize of the Hoechst Company
• 1989 Award of the Association of Physicians in Vienna
• 1989 Award of the President of the Republic of Austria

Selected peer-reviewed publications

• 1. Inghirami G, Szabolcs M.J, Yee H, Cesarman E, and Knowles DM: Detection of immunoglobulin gene rearrangement of B cell non-Hodgkin's lymphomas and leukemias in fresh, unfixed and formalin fixed paraffin embedded tissue by polymerase chain reaction, Lab. Invest 1993, 68:745-756.
• 2. Szabolcs MJ, Seigle R, Shanske S, Bonilla E, DiMauro S, and D'Agati V: Mitochondrial DNA deletion: a cause of chronic tubulointerstitial nephropathy. Kidney Int 1994, 45:1388-1396.
• 3. Yellin MJ, Brett J, Baum D, Matsushima AY, Szabolcs MJ, Stern D and Chess L. Functional interactions of T cells with endothelial cells: The role of CD40L-CD40 mediated signals. J Exp Med 1995, 182: 1857-1864.
• 4. Szabolcs MJ, Visser J, Shelanski ML, Schullinger JN, and O'Toole K: Peripherin: A novel marker for the immunohistochemical study of malformations of the enteric nervous system. Pediatric Path Lab Med 1996, 16: 51-70.
• 5. Chen B-X., Szabolcs MJ, Matsushima AY, Erlanger BF. A strategy for immunohistochemical signal enhancement by end-product amplification. J Histochem Cytochem 1996, 44: 819-824.
• 6. Yang X, Galeno NF, Szabolcs M, Sciacca RR, Cannon PJ. Oxidized low density lipoproteins alter macrophage lipid uptake, apoptosis, viability and nitric oxide synthesis. J Nutr 1996, 126: 1072S-1075S.
• 7. Szabolcs MJ, Michler RE, Yang X, Walif A, Dilip R, Athan E, Sciacca RR, Minanov OP, Cannon PJ. Apoptosis of cardiac myocytes during cardiac allograft rejection: relation to induction of nitric oxide synthase. Circulation 1996; 94: 1665-1673.
• 8. Lanoix J, D'Agati V, Szabolcs M, Trudel M. Dysregulation of cellular proliferation and apoptosis mediates human autosomal dominant polycystic kidney disease (ADPKD). Oncogene 1996, 13: 1153-1160.
• 9. Ravalli S, Szabolcs M, Albala A, Michler RE, Cannon PJ. Increased expression of endothelin-1 in human cardiac allografts: a possible factor in transplant arterioscerosis. Circulation 1996, 94: 2096-2102.
• 10. Aji W., Ravalli S, Szabolcs M, Jiang X-C, Sciacca RR, Michler RE, Cannon PJ. L-Arginie prevents xanthoma development and inhibits atherosclerosis in LDL receptor knockout mice. Circulation 1997; 95:430-437.
• 11. Yellin MJ, D'Agati V, Parkinson G, Soh-Yung Han A, Szema A, Baum D, Estes D, Szabolcs M, Chess L. Immunohistologic analysis of renal CD40 and CD40L expression in systemic lupus erythematodes and other glomerulonephritides. Arthritis Rheum 1997, 40: 124-134.
• 12. Yang X, Szabolcs MJ, Athan E, Minanov OP, Sciacca RR, Bianchi M, Ulrich P, Tracey KJ, Michler RE, Cannon PJ. CNI-1493 prolongs survival and reduces myocyte loss, apoptosis and inflammation during rat cardiac allograft rejection. J Cardiovasc Pharmacol 1998, 32:146-155.
• 13. Ravalli S, Albala A, Ming M, Szabolcs M, Barbone A, Michler RE, Cannon PJ. Inducible nitric oxide synthase expression in smooth muscle cells and macrophages of human transplant coronary artery disease. Circulation 1998, 97:2338-2345.
• 14. Szabolcs MJ, Ravalli S, Minanov OP, Sciacca RR, Michler RE, Cannon PJ. Apoptosis and increased expression of nitric oxide synthase in human cardiac allograft rejection. Transplantation 1998, 65: 804-812.
• 15. Tok J, Szabolcs MJ, Silvers DN, Zhong J, Matsushima AY. Detection of clonal T cell receptor g gene rearrangements by polymerase chain reaction denaturing gradient gel electrophoresis (PCR-DGGE) in archival specimens from patients with early CTCL: correlation of histologic findings with PCR-DGGE. J Am Acad Dermatol 1998, 38:453-460.
• 16. Luo JH, Matsushima AY, Chen R, Szabolcs MJ. The detection of CD5 antigen on B cell lymphomas in fixed, paraffin embedded tissues using catalyzed reporter deposition. Eur J Histochem 1998, 42: 31-39.
• Cannon PJ, Yang X., Szabolcs MJ, Ravalli S, Sciacca RR, Michler RE. The role of inducible nitiric oxide synthase in cardiac allograft rejection. Cardiovas Res 1998, 38: 6-15.
• 17. Minanov OP, Artip JH, Szabolcs M, Kwiatkowski PA, Gailili U, Itescu S, Michler RE. Triple immunosuppression reduces mononuclear cell infiltration and prolongs graft life in pig-to-newborn baboon cardiac xenotransplantation. J Thorac Cardiovasc Surg 1998, 115: 998-1006.
• 18. Windisch A, Gundersen K, Szabolcs MJ, Gruber H, Lomo T. Fast to slow transformation of denervated and electrically stimulated rat muscle. J Physiol (Lond) 1998, 510: 623-632.
• 19. Massey RA, Tok J, Strippoli BA, Szabolcs MJ, Silvers DN, Eliezri YD. A comparison of frozen and paraffin sections in dermatofibrosarcoma protuberans. Dermatol Surg 1998, 24:995-998.
• 20. Starr JP, Jia CX, Amirhamzeh MM, Rabkin DG, Hart JP, Hsu DT, Fisher PE, Szabolcs M, Spotnitz HM. Coronary perfusate composition influences diastolic properties, myocardial water content, and histologic characteristics of the rat left ventricle Ann Thorac Surg. 1999; 68(3):925-30.
• Cannon PJ, Szabolcs MJ. Apoptosis and cardiac allograft rejection: A role for nitric oxide? Cardiovasc Risk Factors 1999; 9(2): 58-66.
• 21. Pinsky DJ, Aji W, Szabolcs M, Athan ES, Liu Y, Yang YM, Kline RP, Olson KE, Cannon PJ. Nitric oxide triggers programmed cell death (apoptosis) of adult rat ventricular myocytes in culture. Am J Physiol. 1999; 277(3 Pt 2):H1189-99.
• 22. Yang X, Ma N, Szabolcs MJ, Zhong J, Athan E, Sciacca RR, Michler RE, Anderson GD,Wiese JF, Leahy KM, Gregory S, Cannon PJ. Upregulation of COX-2 during cardiac allograft rejection. Circulation. 2000;101(4):430-438
• 23. Kline RP, Wu EX, Petrylak DP, Szabolcs M, Alderson PO, Weisfeldt ML, Cannon P, Katz J. Rapid in vivo monitoring of chemotherapeutic response using weighted sodium magnetic resonance imaging Clin Cancer Res. 2000; 6(6):2146-56.
• 24. Szabolcs MJ, Cannon PJ, Thienel U, Chen R, Michler RE, Chess L, Yellin MJ. Analysis of CD154 and CD40 expression in native coronary atherosclerosis and transplant associated coronary artery disease. Virchows Arch. 2000; 437(2):149-59.
• 25. Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, Wang J, Homma S, Edwards NM, Itescu S. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001; 7:430-436.
• 26. Szabolcs MJ, Ma N, Athan E, Zhong J, Ming Ming, Sciacca RR, Husemann J, Albala A, Cannon PJ. Acute cardiac allograft rejection in nitric oxide synthase-2-/- and nitric oxide synthase-2+/+ mice: effects of cellular chimeras on myocardial inflammation and cardiomyocyte damage and apoptosis. Circulation 2001; 103:2514-2520.
• 27. Pirog EC, Isacson C, Szabolcs MJ, Kleter B, Quint W, Richart RM. Proliferative activity of benign and neoplastic endocervical epithelium and correlation with HPV DNA detection. Int J Gynecol Pathol. 2002; 21:22-26.
• 28. Szabolcs MJ, Sun J, Ma Ningsheng, Albala A, Sciacca RR, Philips GB:, Parkinson J, Niloo E, Cannon PJ. Effects of selective inhibitors of nitric oxide synthase-2 dimerization on acute cardiac allograft rejection. Circulation 2002; 106:2392-2396.
• 29. Ma N, Szabolcs MJ, Sun J, Albala A, Sciacca RR, Zhong M, Edwards N, Cannon PJ. The effect of selective inhibition of cyclooxygenase (COX)-2 on acute cardiac allograft rejection. Transplantation. 2002;74(11):1528-3